DIM/Chrysin

Recommendations: One mL (1 mL indicated on the dropper) under the tongue daily (shake bottle before use and insure the patient retains Liposomal DIM/Chrysin under their tongue for at least 30 seconds. Liposomal DIM/Chrysin should be refrigerated after use and after opening should be discarded after 45 days. Liposomal DIM/Chrysin should not be used during pregnancy or lactation.

Availability: Liposomal DIM/Chrysin is available in a 1 ounce (30ml) bottle.

Liposomal DIM/Chrysin is a proprietary blend (28 mg per serving) of diindolylmethane (commonly known as DIM), extracted from cruciferous vegetables and chrysin, extracted from passionflower, microencapsulated and layered in a highly emulsified lipid sphere. This sphere, a liposome, is able to transport via sublingual absorption, a hydrophilic substance in a lipophillic capsule to the tissues and release it for absorption. The enzymes in the mouth breakdown the liposome and allow the proprietary blend of DIM and chrysin to be released into the tissue. This process effectively bypasses the gut where absorption for most patients is significantly limited (Twalle and Associates, British Journal of Pharmacology – average absorption of 400 mg oral dose was 3-16 ng/mL of plasma). According to the peer literature, liposome absorption is generally greater than 85 percent.

Clinical Considerations:

  • Liposomal DIM/Chrysin is a natural inhibitor of aromatase, the enzyme that transforms testosterone to estrogen in both men and women. This conversion is thought to be one of the major risk factors for testosterone treatment failure (J. Wright and Associates, Townsend Letter and Pizzorno and Associates, Longevity Medicine Review).
  • Liposomal DIM/Chrysin is effective as adjunctive support with several types of cancer (Mani and Natesan, Phytochemistry). Liposomal Chrysin will suppress active oxygen species and will inhibit platelet aggregation (Mani and Natesan, Phytochemistry).
  • Liposomal DIM is effective in adjusting estrogen metabolism to increase the 2-hydroxy form of estrogen and decrease the 16-hydroxy form of estrogen (increase good form and decrease bad form). An increased 16 to 2 ratio is seen with many cases of feminizing cancer, elevated prostate specific antigen (PSA) levels and systemic lupus, J. Wright and Associates, Townsend Letter.
  • Unlike soy flavones, red clover and other phytoestrogens, Liposomal DIM is not an estrogen mimic or phytoestrogen and has no estrogenic activity.
  • Liposomal DIM will decrease the increased level of 16-hydroxy estrogen seen with exposure to dieldrin and other estrogenic
    pesticides. This is a very important point if you are a golfer, farmer or are routinely exposed to pesticides or other estrogenic
    compounds. (Wright and Associates,, Townsend Letter).
  • DIM Enhances Glucose Uptake Through Activation of Insulin Signaling 3T3-L1 Adipocytes, (Chio and Yoo, Obesity (Silver-
    Spring).
  • Liposomal DIM increases bone mass by suppressing osteoclastic bone reabsorption, Yu and Associates, Journal of Pharmacol Science.

Liposomal DIM/Chrysin is a proprietary blend (28 mg per serving) of diindolylmethane (commonly known as DIM), extracted from cruciferous vegetables and chrysin, extracted from passionflower, microencapsulated and layered in a highly emulsified lipid sphere. This sphere, a liposome, is able to transport via sublingual absorption, a hydrophilic substance in a lipophillic capsule to the tissues and release it for absorption. The enzymes in the mouth breakdown the liposome and allow the proprietary blend of DIM and chrysin to be released into the tissue. This process effectively bypasses the gut where absorption for most patients is significantly limited (Twalle and Associates, British Journal of Pharmacology – average absorption of 400 mg oral dose was 3-16 ng/mL of plasma). According to the peer literature, liposome absorption is generally greater than 85 percent.

Clinical Considerations:

  • Liposomal DIM/Chrysin is a natural inhibitor of aromatase, the enzyme that transforms testosterone to estrogen in both men and women. This conversion is thought to be one of the major risk factors for testosterone treatment failure (J. Wright and Associates, Townsend Letter and Pizzorno and Associates, Longevity Medicine Review).
  • Liposomal DIM/Chrysin is effective as adjunctive support with several types of cancer (Mani and Natesan, Phytochemistry). Liposomal Chrysin will suppress active oxygen species and will inhibit platelet aggregation (Mani and Natesan, Phytochemistry).
  • Liposomal DIM is effective in adjusting estrogen metabolism to increase the 2-hydroxy form of estrogen and decrease the 16-hydroxy form of estrogen (increase good form and decrease bad form). An increased 16 to 2 ratio is seen with many cases of feminizing cancer, elevated prostate specific antigen (PSA) levels and systemic lupus, J. Wright and Associates, Townsend Letter.
  • Unlike soy flavones, red clover and other phytoestrogens, Liposomal DIM is not an estrogen mimic or phytoestrogen and has no estrogenic activity.
  • Liposomal DIM will decrease the increased level of 16-hydroxy estrogen seen with exposure to dieldrin and other estrogenic pesticides. This is a very important point if you are a golfer, farmer or are routinely exposed to pesticides or other estrogenic compounds. (Wright and Associates,, Townsend Letter).
  • DIM Enhances Glucose Uptake Through Activation of Insulin Signaling 3T3-L1 Adipocytes, (Chio and Yoo, Obesity (Silver-Spring).
  • Liposomal DIM increases bone mass by suppressing osteoclastic bone reabsorption, Yu and Associates, Journal of Pharmacol Science.

Recommendations: One mL (1 mL indicated on the dropper) under the tongue daily (shake bottle before use and insure the patient retains Liposomal DIM/Chrysin under their tongue for at least 30 seconds. Liposomal DIM/Chrysin should be refrigerated after use and after opening should be discarded after 45 days. Liposomal DIM/Chrysin should not be used during pregnancy or lactation.

Availability: Liposomal DIM/Chrysin is available in a 1 ounce (30ml) bottle.